Open AccessSerum adiponectin among different stages of type 2 diabetes mellitus patients
Author(s) -
R Basavaraj,
Ravikumar Malladad
Publication year - 2021
Publication title -
pathology update
Language(s) - English
Resource type - Journals
ISSN - 2456-9887
DOI - 10.17511/jopm.2021.i04.01
Subject(s) - microalbuminuria , adiponectin , creatinine , medicine , uric acid , diabetic nephropathy , type 2 diabetes mellitus , nephropathy , diabetes mellitus , gastroenterology , endocrinology , type 2 diabetes , insulin resistance
Background: Type 2 diabetes mellitus is a chronic metabolic disorder that leads to micro andmacrovascular complications. Nephropathy is the most common microvascular complication. Fordiagnosis of nephropathy in T2DM patients by using urinary albumin, this is not a sensitive andspecific biomarker because it is elevated in other conditions. we aimed to evaluate the serumadiponectin for early detection of nephropathy in patients with type 2 diabetes mellitus. Methods: Atotal of 60 subjects were included in the present study and further subdivided into 30 patients T2DMwith normoalbuminuria, 30 patients with microalbuminuria. All the patients were included afterobtaining institutional ethical permission and consent forms. Blood and urine samples were collectedfrom all the subjects and proceed with further analysis. Appropriate statistical analyses were usedfor different types of data analysis. Results: Increased levels of FBS, PPBS, HbA1C and serumadiponectin were observed in two groups of T2DM patients. Statistically elevated levels of serumUrea, Creatinine and Uric acid levels were observed in patients T2DM with microalbuminuria whencompared to T2DM with normoalbuminuria. The serum adiponectin was positively correlated withFBS, PPBS, HbA1C, Urea, Creatinine, Uric Acid and Urinary Albumin in patients with two groups ofT2DM. Conclusion: This study concluded that measuring the serum adiponectin levels may beuseful for the early detection of nephropathy in patients with T2DM.