Open AccessThe effect of prophylactic use of intravenous tranexamic acid in abdominal hysterectomy
Author(s) -
Smita Barya,
Sameer Goyal
Publication year - 2021
Publication title -
obsgyne review journal of obstetric and gynecology of siddharth health research and social welfare society
Language(s) - English
Resource type - Journals
ISSN - 2581-4389
DOI - 10.17511/joog.2021.i01.01
Subject(s) - tranexamic acid , medicine , abdominal hysterectomy , hysterectomy , blood loss , saline , anesthesia , surgery , randomized controlled trial
Hysterectomy is one of the frequently performed major gynecological surgicalprocedures for various uterine pathologies. The objective of this study is to assess the effect ofintravenous tranexamic acid in reducing intraoperative and postoperative blood loss in womenundergoing abdominal hysterectomy. Materials and Methods: The study was a randomizeddouble-blind study, involving a total of 120 women undergoing abdominal hysterectomy for benignetiology were randomly assigned to two groups: Group 1 (non TA): (n=60) women receiving normalsaline and Group 2 (TA): (n=60) women receiving prophylactic Tranexamic Acid in 100 ml saline IVjust before skin incision. The primary outcome was intraoperative, postoperative, and all blood lossestimation. Results: Group 2 (TA) showed a great reduction in intraoperative and postoperativeblood loss (blood in the intra-abdominal drain) compared with Group 1 (non TA), (P = 0.0001,0.0001), so the overall estimated blood loss in groups 2 showed significant reduction compared withGroup 1 (P = 0.0001). Conclusion: Intravenous tranexamic acid is a safe and reliable method tohelp decrease blood loss during and after abdominal hysterectomy.