Open AccessPreparation and characterization of Copper Chitosan Nanocomposites with Antibacterial Activity for Applications in Tissue Engineering
Author(s) -
Kyle Lara,
Gabriel Luna Bárcenas,
E. Hernández,
Felipe Padilla Vaca,
E. Hernández Sánchez,
Rebeca BetancourtGalindo,
Jorge Luis Menchaca-Arredondo,
Beatriz Liliana EspañaSánchez
Publication year - 2015
Publication title -
revista mexicana de ingeniería biomédica
Language(s) - English
Resource type - Journals
eISSN - 2395-9126
pISSN - 0188-9532
DOI - 10.17488/rmib.38.1.26
Subject(s) - nanocomposite , chitosan , biopolymer , antibacterial activity , nanoparticle , nanomaterials , fourier transform infrared spectroscopy , chemical engineering , copper , chemistry , materials science , nanotechnology , nuclear chemistry , polymer , organic chemistry , bacteria , biology , engineering , genetics
The Present work describes the preparation of nanocomposites based on chitosan (QS)/copper nanoparticles (nCu) with antibacterial properties and potential application in tissue engineering. For this purpose, nanocomposites were prepared by solution blending with ultrasound assisted, aiming to increase the nanoparticles dispersion in the biopolymer. FTIR analyses demonstrates that nCu supported in QS increase their interaction of nanoparticles with amine/hydroxyl groups of QS molecule. UV-Vis analyses demonstrates that QS/nCu nanocomposites have an absorption signal associated with the presence of nanoparticles and the possible Cu2+ ions release in liquid media. AFM analyses shown that hydrated QS form a mesh with micro pores, improving the bacterial penetration and the direct contact with nCu. This behavior was corroborated by antibacterial assays, where QS/nCu nanocomposites shown an antibacterial activity higher than 90% between 90-180 minutes of interaction. Our results suggest that is possible to obtain combined antibacterial/biocompatible nanomaterials with potential application in tissue engineering.