Open AccessFresh frozen plasma as a source of plasminogen for ligneous conjunctivitis: Case report and a review of the literature
Author(s) -
Park Benjamin J,
Camoriano David,
Vital Mark C,
Chévez-Barrios Patricia,
Goosey John D,
Belloso Marcel
Publication year - 2021
Publication title -
journal of clinical research and ophthalmology
Language(s) - English
Resource type - Journals
ISSN - 2455-1414
DOI - 10.17352/2455-1414.000090
Subject(s) - medicine , fresh frozen plasma , surgery , debridement (dental) , dermatology , platelet
Purpose: To describe management of a patient with ligneous conjunctivitis secondary to plasminogen deficiency and review the literature on treatment with plasminogen. Design: Interventional case report. Methods: A 6-year-old Caucasian girl developed ligneous conjunctivitis recalcitrant to debridement and treatment with topical cyclosporin A and steroids. The literature was reviewed regarding treatment of ligneous conjunctivitis with plasminogen. Results: The patient was treated with plasminogen containing drops derived from her father’s fresh frozen plasma. The ligneous conjunctivitis resolved, and the patient was managed on these drops for the following 8 years, initiating treatment for flares and tapering according to clinical response. Conclusions: Plasminogen drops concentrated from fresh frozen plasma are a safe and effective option for long-term treatment of ligneous conjunctivitis.