Fresh frozen plasma as a source of plasminogen for ligneous conjunctivitis: Case report and a review of the literature | Zendy

Park Benjamin J | Zendy; Camoriano David | Zendy; Vital Mark C | Zendy; Chévez-Barrios Patricia | Zendy; Goosey John D | Zendy; Belloso Marcel | Zendy

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Fresh frozen plasma as a source of plasminogen for ligneous conjunctivitis: Case report and a review of the literature

Author(s) -

Park Benjamin J,

Camoriano David,

Vital Mark C,

Chévez-Barrios Patricia,

Goosey John D,

Belloso Marcel

Publication year - 2021

Publication title -

journal of clinical research and ophthalmology

Language(s) - English

Resource type - Journals

ISSN - 2455-1414

DOI - 10.17352/2455-1414.000090

Subject(s) - medicine , fresh frozen plasma , surgery , debridement (dental) , dermatology , platelet

Purpose: To describe management of a patient with ligneous conjunctivitis secondary to plasminogen deficiency and review the literature on treatment with plasminogen. Design: Interventional case report. Methods: A 6-year-old Caucasian girl developed ligneous conjunctivitis recalcitrant to debridement and treatment with topical cyclosporin A and steroids. The literature was reviewed regarding treatment of ligneous conjunctivitis with plasminogen. Results: The patient was treated with plasminogen containing drops derived from her father’s fresh frozen plasma. The ligneous conjunctivitis resolved, and the patient was managed on these drops for the following 8 years, initiating treatment for flares and tapering according to clinical response. Conclusions: Plasminogen drops concentrated from fresh frozen plasma are a safe and effective option for long-term treatment of ligneous conjunctivitis.

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