Open Access6-Bromo-2’-(2-chlorobenzylidene)nicotinohydrazide and 6-Bromo-2’-(3-bromo-5-chloro-2-hydroxybenzylidene) nicotinohydrazide Methanol Solvate: Synthesis, Characterization, Crystal Structures and Antimicrobial Activities
Author(s) -
Hai-Yun Zhu
Publication year - 2021
Publication title -
acta chimica slovenica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.289
H-Index - 46
eISSN - 1580-3155
pISSN - 1318-0207
DOI - 10.17344/acsi.2020.6138
Subject(s) - methanol , hydrogen bond , molecule , chemistry , hydrazone , antimicrobial , crystal structure , crystal (programming language) , medicinal chemistry , stereochemistry , combinatorial chemistry , crystallography , organic chemistry , computer science , programming language
Two newly synthesized nicotinohydrazones, 6-bromo-2’-(2-chlorobenzylidene)nicotinohydrazide (1) and 6-bromo-2’-(3-bromo-5-chloro-2-hydroxybenzylidene)nicotinohydrazide methanol solvate (2), have been obtained and structurally characterized by spectroscopic method and single crystal X-ray determination. The molecules in both compounds are in E configuration regarding to the azomethine groups. The molecules of compound 1 are linked via hydrogen bonds of N−H∙∙∙O, generating one dimensional chains running along the c-axis direction. The hydrazone molecules of compound 2 are linked by methanol molecules via hydrogen bonds of N−H∙∙∙O and O−H∙∙∙N, generating dimers. The in vitro antimicrobial activities of these compounds indicate that they are interesting antibacterial agents.