Open AccessSynthesis, Characterization and Crystal Structures of Fluoro-Substituted Aroylhydrazones with Antimicrobial Activity
Author(s) -
Fuming Wang,
Lijie Li,
Guo-Wei Zang,
Tongtong Deng,
You Zhang
Publication year - 2021
Publication title -
acta chimica slovenica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.289
H-Index - 46
eISSN - 1580-3155
pISSN - 1318-0207
DOI - 10.17344/acsi.2020.6051
Subject(s) - bacillus subtilis , antimicrobial , candida albicans , chemistry , aspergillus niger , staphylococcus aureus , antibacterial activity , escherichia coli , nuclear chemistry , microbiology and biotechnology , fluorescence , bacteria , organic chemistry , biochemistry , biology , genetics , physics , quantum mechanics , gene
A series of five new fluoro-substituted aroylhydrazones were prepared and structurally characterized by elemental analysis, IR, UV-Vis and 1H NMR spectroscopy, as well as single crystal X-ray diffraction. The compounds were evaluated for their antibacterial (Bacillus subtilis, Staphylococcus aureus, Escherichia coli, and Pseudomonas fluorescence) and antifungal (Candida albicans and Aspergillus niger) activities by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) method. The biological assay indicated that the presence of the electron-withdrawing groups in the aroylhydrazones improved their antimicrobial activities.