Synthesis, Characterization and Crystal Structures of Fluoro-Substituted Aroylhydrazones with Antimicrobial Activity | Zendy

FuMing Wang | Zendy; Lijie Li | Zendy; Guo-Wei Zang | Zendy; Tongtong Deng | Zendy; ZhongLu You | Zendy

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Synthesis, Characterization and Crystal Structures of Fluoro-Substituted Aroylhydrazones with Antimicrobial Activity

Author(s) -

FuMing Wang,

Lijie Li,

Guo-Wei Zang,

Tongtong Deng,

ZhongLu You

Publication year - 2021

Publication title -

acta chimica slovenica

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.289

H-Index - 46

eISSN - 1580-3155

pISSN - 1318-0207

DOI - 10.17344/acsi.2020.6051

Subject(s) - bacillus subtilis , antimicrobial , candida albicans , chemistry , staphylococcus aureus , aspergillus niger , antibacterial activity , escherichia coli , nuclear chemistry , microbiology and biotechnology , fluorescence , bacteria , organic chemistry , biochemistry , biology , genetics , physics , quantum mechanics , gene

A series of five new fluoro-substituted aroylhydrazones were prepared and structurally characterized by elemental analysis, IR, UV-Vis and 1H NMR spectroscopy, as well as single crystal X-ray diffraction. The compounds were evaluated for their antibacterial (Bacillus subtilis, Staphylococcus aureus, Escherichia coli, and Pseudomonas fluorescence) and antifungal (Candida albicans and Aspergillus niger) activities by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) method. The biological assay indicated that the presence of the electron-withdrawing groups in the aroylhydrazones improved their antimicrobial activities.

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