Open AccessVoltammetric Assay of Metformin Hydrochloride Using Pyrogallol Modified Carbon Paste Electrode
Author(s) -
Attia Ak,
Salem Wm,
Mona Am
Publication year - 2015
Publication title -
acta chimica slovenica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.289
H-Index - 46
eISSN - 1580-3155
pISSN - 1318-0207
DOI - 10.17344/acsi.2014.950
Subject(s) - pyrogallol , detection limit , chemistry , differential pulse voltammetry , carbon paste electrode , hydrochloride , cyclic voltammetry , voltammetry , electrode , nuclear chemistry , metformin hydrochloride , chromatography , electrochemistry , inorganic chemistry , metformin , organic chemistry , medicine , diabetes mellitus , endocrinology
The electrooxidative behavior and determination of metformin hydrochloride, anti-hyperglycemic drug, on a pyrogallol modified carbon paste electrode were investigated using cyclic voltammetry and differential pulse voltammetry. Metformin hydrochloride shows an irreversible oxidation behavior over a wide interval of pH (Britton-Robinson buffers, pH 2-9). The peak current varied linearly in the range comprised between 8.0 × 10(-7) and 6.0 × 10(-6) mol/L with detection limit of 6.63 × 10(-8) mol/L and limit of quantification of 2.21 × 10(-7) mol/L. The method was proposed for the determination of metformin hydrochloride in dosage forms and urine.