Open AccessAstrocytes and human artificial blood-brain barrier models
Author(s) -
Tanja Zidarič,
Lidija Gradišnik,
Tomaž Velnar
Publication year - 2022
Publication title -
bosnian journal of basic medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 25
eISSN - 1840-4812
pISSN - 1512-8601
DOI - 10.17305/bjbms.2021.6943
Subject(s) - blood–brain barrier , astrocyte , medicine , central nervous system , immune system , in vitro , neuroscience , human brain , immunology , biology , biochemistry
The blood-brain barrier (BBB) functions as a highly selective border of endothelial cells, protecting the central nervous system from potentially harmful substances by selectively controlling the entry of cells and molecules, including components of the immune system. To study the BBB properties, find suitable therapies, and identify new drug targets, there is a need to develop representative in vitro BBB models. In this article, we describe the astrocyte roles in the BBB functioning and human in vitro BBB models.