Open AccessSmall cell variant of chromophobe renal cell carcinoma: Clinicopathologic, and molecular-genetic analysis of 10 cases.
Author(s) -
Joanna Rogala,
Fumiyoshi Kojima,
Reza Alaghehbandan,
Nikola Ptáková,
Ana Bravc,
Stela Bulimbašić,
Delia Pérez Montiel,
Maryna Slisarenko,
Leila Ali,
Levente Kuthi,
Kristýna Pivovarčíková,
Květoslava Michalová,
Boris Bartovic,
Adriena Bartos Vesela,
Olga Dolejšová,
Michal Michal,
Ondřej Hes
Publication year - 2022
Publication title -
bosnian journal of basic medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 25
eISSN - 1840-4812
pISSN - 1512-8601
DOI - 10.17305/bjbms.2021.6935
Subject(s) - clear cell , pathology , chromophobe cell , clear cell renal cell carcinoma , medicine , cd117 , population , trichoepithelioma , immunohistochemistry , renal cell carcinoma , biology , basal cell carcinoma , cd34 , basal cell , genetics , stem cell , environmental health
Chromophobe renal cell carcinoma (CHRCC) is known for morphologic variability. Besides classic morphology, several other patterns like pigmented adenomatoid, multicystic, even papillary were documented.
10 cases of CHRCC composed of small cell population in various percentages that were analysed using morphologic parameters, immunohistochemistry and next generation sequencing.
Patients were 5 males and 5 females with 40-78 age range. Size of tumors ranged from 2.2 cm to 11 cm (mean 5.17 cm).
Small cell component comprised 10-80% of total tumor volume, the rest was formed by cells with classic morphology. Immunohistochemical profile followed typical CHRCC immunophenotype with positivity for CD117, CK7 among others. Neuroendocrine markers were negative. Mutations of 13 genes were found: DCIER1, FGFR3, JAK3, SUFO, FAM46C, FANCG, MET, PLCG2, APC, POLE, EPICAM, MUTYH, AR. However, only mutation of PLCG2 is listed as pathogenic.
Recognition of small cell variant of CHRCC is not problematic in tumors, where “classic” CHRCC component is present. In limited material, like core biopsy, recognising this pattern could be troublesome. Very problematic might be in limited material like core biopsy. From our limited data it seems, that small cell morphology has no influence on prognosis.