Open AccessTrazodone influence on rat sera beta-endorphins level
Author(s) -
Radivoj Jadrić,
İrfan Zulić,
Sabaheta Hasić,
Emina Kiseljaković,
B Zecević,
Jovan Radovanović,
Emina Ićindić-Nakaš,
Mira Winterhalter-Jadrić
Publication year - 2004
Publication title -
bosnian journal of basic medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 25
eISSN - 1840-4812
pISSN - 1512-8601
DOI - 10.17305/bjbms.2004.3411
Subject(s) - medicine , endorphins , trazodone , beta (programming language) , endocrinology , pharmacology , antidepressant , computer science , programming language , hippocampus
Some 25 years ago it was found that parts of CNS could produce strong analgesic response on little morphine quantities. Later studies proved the existence for dozen of morphine-like substances, called opioids, which are normally produced in the brain. The most important are endorphins, met- and leu-encephalin and dinorphin produced both in hypothalamus and pituitary gland. The aim of our study was to found whether and how strong produce of beta-endorphins is to be expected when psychotropic drugs are used. Trazodon as antidepressant was used, and RIA technique for quantification of sera beta-endorphins. The results showed significant difference in rat sera beta-endorphinsbetween certain days of drug application. These studies showed that beta-endorphins could be of great importance, used as markers for evaluation of patient treatment and eventual abuse of psychotropic drugs.