Open AccessMetastatic lesion of choroidal melanoma located in the head of pancreas
Author(s) -
Javier Rodriguez,
Julio Osuna Soto,
Emilia Victoria Perdices López
Publication year - 2022
Publication title -
revista española de enfermedades digestivas/revista española de enfermedades digestivas
Language(s) - English
Resource type - Journals
eISSN - 2340-4167
pISSN - 1130-0108
DOI - 10.17235/reed.2022.8843/2022
Subject(s) - medicine , pembrolizumab , nivolumab , ipilimumab , pancreas , melanoma , immunotherapy , oncology , gastroenterology , cancer research , cancer
Metastases in pancreas are uncommon, ranging from 2 to 5 % of pancreatic malignancies. Choroidal melanoma is rare, and less than 1% spread to the pancreas. It can cause obstructive jaundice if it affects the pancreatic head region. Advanced disease is associated with poor prognosis, however immunotherapy with PD-1 inhibitors (nivolumab or pembrolizumab), alone or in combination with anti-CTLA-4 antibodies (ipilimumab), has shown an increase in survival.