Open AccessCan inflammatory biomarkers help in the diagnosis and prognosis of gangrenous acute cholecystitis? A prospective study
Author(s) -
José Ángel Díez Ares,
Rosario Martínez García,
Nuria Estellés Vidagany,
Nuria Peris Tomás,
Manuel Planells Roig,
Marta Valenzuela Gras,
T. Ripollés González
Publication year - 2020
Publication title -
revista española de enfermedades digestivas/revista española de enfermedades digestivas
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.331
H-Index - 38
eISSN - 2340-4167
pISSN - 1130-0108
DOI - 10.17235/reed.2020.7282/2020
Subject(s) - medicine , procalcitonin , odds ratio , prospective cohort study , cholecystitis , gastroenterology , gangrene , neutrophil to lymphocyte ratio , c reactive protein , area under the curve , cholecystectomy , receiver operating characteristic , lymphocyte , surgery , sepsis , gallbladder , inflammation
The diagnosis of gangrenous acute cholecystitis represents a diagnostic challenge for the physician and is rarely identified preoperatively. We report a longitudinal prospective study in 180 patients who underwent cholecystectomy for acute cholecystitis. A ROC curve was obtained to determine the preoperative cut-off for various biomarkers (neutrophil to lymphocyte ratio [NLR], C-reactive protein [CRP], platelet to lymphocyte ratio [PLR], lactate and procalcitonin) and their association with both preoperative and postoperative findings. The area under the curve (AUC) for NLR, CRP, PLR, lactate and procalcitonin was 0.75, 0.8, 0.65 and 0.6, respectively. NLR > 5 and CRP > 100 are still independent factors for gangrene (adjusted odds ratio [OR], 2 and 2.1, respectively).