PRELIMINARY EXPERIENCE IN MAINTENANCE TREATMENT WITH INTRAVENOUS USTEKINUMAB AS A RESCUE FOR LOSS OF RESPONSE TO SUBCUTANEOUS DOSES | Zendy

Isabel Pérez Valle | Zendy; Pilar Varela Trastoy | Zendy; Alejo Mancebo Mata | Zendy

Open Access

PRELIMINARY EXPERIENCE IN MAINTENANCE TREATMENT WITH INTRAVENOUS USTEKINUMAB AS A RESCUE FOR LOSS OF RESPONSE TO SUBCUTANEOUS DOSES

Author(s) -

Isabel Pérez Valle,

Pilar Varela Trastoy,

Alejo Mancebo Mata

Publication year - 2020

Publication title -

revista española de enfermedades digestivas

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.331

H-Index - 38

eISSN - 2340-4167

pISSN - 1130-0108

DOI - 10.17235/reed.2020.7230/2020

Subject(s) - medicine , ustekinumab , maintenance therapy , rescue therapy , crohn's disease , complete response , surgery , maintenance dose , disease , chemotherapy , adalimumab

It has been demonstrated that ustekinumab (UST) is effective as an induction and maintenance therapy in patients with Crohn's disease (CD). However, a significant number of patients experience an insufficient response or a secondary non-response. We report six cases from our center that underwent a rescue treatment by changing maintenance treatment to weight-adjusted intravenous UST, obtaining a subsequent clinical improvement.

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