Open AccessPRELIMINARY EXPERIENCE IN MAINTENANCE TREATMENT WITH INTRAVENOUS USTEKINUMAB AS A RESCUE FOR LOSS OF RESPONSE TO SUBCUTANEOUS DOSES
Author(s) -
Isabel Pérez Valle,
Pilar Varela Trastoy,
Alejo Mancebo Mata
Publication year - 2020
Publication title -
revista española de enfermedades digestivas/revista española de enfermedades digestivas
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.331
H-Index - 38
eISSN - 2340-4167
pISSN - 1130-0108
DOI - 10.17235/reed.2020.7230/2020
Subject(s) - medicine , ustekinumab , maintenance therapy , rescue therapy , crohn's disease , complete response , surgery , maintenance dose , disease , chemotherapy , adalimumab
It has been demonstrated that ustekinumab (UST) is effective as an induction and maintenance therapy in patients with Crohn's disease (CD). However, a significant number of patients experience an insufficient response or a secondary non-response. We report six cases from our center that underwent a rescue treatment by changing maintenance treatment to weight-adjusted intravenous UST, obtaining a subsequent clinical improvement.