Open AccessVedolizumab for treatment of chronic refractory pouchitis: a systematic review with pool analysis
Author(s) -
Davide Giuseppe Ribaldone,
Rinaldo Pellicano,
Giorgio Maria Saracco,
Mario Morino,
Marco Astegiano
Publication year - 2019
Publication title -
revista española de enfermedades digestivas/revista española de enfermedades digestivas
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.331
H-Index - 38
eISSN - 2340-4167
pISSN - 1130-0108
DOI - 10.17235/reed.2019.6336/2019
Subject(s) - pouchitis , vedolizumab , medicine , refractory (planetary science) , ulcerative colitis , context (archaeology) , systematic review , medline , gastroenterology , disease , physics , astrobiology , paleontology , political science , law , biology
about 1%-2% of patients with chronic refractory pouchitis, in the context of ulcerative colitis, end up with a permanent ileostomy. The aim of this systematic review was to collect all published studies involving patients treated with vedolizumab for chronic refractory or antibiotic-dependent pouchitis and then pool the data regarding the effectiveness of this therapeutic strategy.