Open AccessAltered expression of COX-2 and TNF-a in patients with hepatocellular carcinoma
Author(s) -
Andressa de Freitas Alves,
Vanessa Dido Baldissera,
Eduardo Cremonese Filippi Chiela,
Carlos Thadeu Schmidt Cerski,
Paulo Roberto Ott Fontes,
Marilda da Cruz Fernandes,
Marilene Porawski,
Márcia Giovenardi
Publication year - 2019
Publication title -
revista española de enfermedades digestivas/revista española de enfermedades digestivas
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.331
H-Index - 38
eISSN - 2340-4167
pISSN - 1130-0108
DOI - 10.17235/reed.2019.5898/2018
Subject(s) - medicine , hepatocellular carcinoma , immunohistochemistry , inflammation , tumor necrosis factor alpha , pathology , staining , cancer , estrogen receptor , breast cancer
hepatocellular carcinoma is a type of cancer related with inflammation, as 90% of cases develop in a chronic inflammation condition. Excess inflammation can affect tissue homeostasis. Cytokines and inflammatory mediators are immunological components that can influence the functioning of cells and tissues. In addition, the estrogen receptor appears to play an important role in hepatocarcinogenesis. The aim of the study was to evaluate the expression of inflammatory markers and ER in patients with hepatocellular carcinoma.