Open AccessIs prophylactic gastrectomy indicated for healthy carriers of CDH1 gene mutations associated with hereditary diffuse gastric cancer?
Author(s) -
Vicente Munítiz,
Pilar Jimeno,
David Ruíz de Angulo,
A. S. Ortiz,
Luisa F. Martínez de Haro,
Miguel Marín,
Pedro Cascales,
Gema Ruiz García,
Eduardo Ortiz Ruiz,
Pascual Parrilla
Publication year - 2018
Publication title -
revista española de enfermedades digestivas/revista española de enfermedades digestivas
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.331
H-Index - 38
eISSN - 2340-4167
pISSN - 1130-0108
DOI - 10.17235/reed.2018.5831/2018
Subject(s) - medicine , cdh1 , prophylactic surgery , gastrectomy , cancer , family history , adenocarcinoma , mutation , gastroenterology , oncology , pathology , gene , genetics , cadherin , ovarian cancer , cell , biology
hereditary diffuse gastric cancer (HDGC) is a recently reported hereditary cancer syndrome. Patients with suspected HDGC must be under surveillance via endoscopy and multiple biopsies. As an alternative, some studies suggest prophylactic gastrectomy (PG) for disease carriers. The goal of this article was to report our experience with a CDH1 mutation positive family who underwent PG.