Open AccessEvaluation of serum human epididymis protein 4 in patients with relapsing-remitting multiple sclerosis
Author(s) -
Bożena Adamczyk,
Robert Partyka,
Monika Adamczyk-Sowa,
Krzysztof Wierzbicki,
Paweł Sowa,
Danuta Kokocińska
Publication year - 2020
Publication title -
advances in clinical and experimental medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.486
H-Index - 27
eISSN - 2451-2680
pISSN - 1899-5276
DOI - 10.17219/acem/121006
Subject(s) - medicine , multiple sclerosis , expanded disability status scale , epididymis , oncology , gastroenterology , immunology , sperm , andrology
So far, little is known about the properties of human epididymis protein 4 (HE4) in multiple sclerosis (MS). This type 4 glycoprotein belongs to a family of genes encoding proteins whose expression is associated with the process of spermatogenesis in the epididymis. The biological function of HE4 is not fully understood. Overexpression of HE4 has been found in several malignant tumors, particularly in ovarian cancer, as well as in mesothelioma, lung, endometrial, breast, and kidney cancers.