Open AccessSerum concentration of osteopontin and interleukin 17 in psoriatic patients
Author(s) -
Joanna Przepiórka-Kosińska,
Joanna Bartosińska,
Dorota Raczkiewicz,
Iwona Bojar,
Jakub Kosiński,
Dorota Krasowska,
Grażyna Chodorowska
Publication year - 2020
Publication title -
advances in clinical and experimental medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.486
H-Index - 27
eISSN - 2451-2680
pISSN - 1899-5276
DOI - 10.17219/acem/112604
Subject(s) - psoriasis , medicine , pathogenesis , interleukin 17 , psoriasis area and severity index , cd8 , osteopontin , interleukin , immunology , body mass index , body surface area , context (archaeology) , interleukin 22 , gastroenterology , immune system , cytokine , biology , paleontology
Psoriasis is a chronic, autoinflammatory disease characterized by activation and differentiation of naive T lymphocytes towards T helper CD4+ (including Th1 and Th17) and T cytotoxic CD8+. Osteopontin (OPN), which plays an important role in both physiological processes and inflammatory, neoplastic and autoimmune diseases, is also considered in the context of psoriasis pathogenesis. Current data indicates that OPN is a multifunctional protein involved in the modulation of Th1 and Th17 cellular responses, in stimulating keratinocyte proliferation, and in the regulation of cellular apoptosis.