Open AccessSleep disorders in Amyotrophic Lateral Sclerosis
Author(s) -
Sireesha Murala,
Nakul Katyal,
Naureen Narula,
Raghav Govindarajan,
Pradeep Sahota
Publication year - 2021
Publication title -
rrnmf neuromuscular journal
Language(s) - English
Resource type - Journals
ISSN - 2692-3092
DOI - 10.17161/rrnmf.v2i4.15293
Subject(s) - amyotrophic lateral sclerosis , medicine , hypoventilation , sleep disorder , central sleep apnea , insomnia , sleep (system call) , obstructive sleep apnea , physical medicine and rehabilitation , pediatrics , polysomnography , apnea , disease , psychiatry , respiratory system , operating system , computer science
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder affecting both the central and peripheral nervous system. The median survival rate for ALS patients after symptom onset is 2.5 to 3.5 years and after diagnosis of ALS is about 1.5 to 2.5 years. Patients with ALS can have a wide spectrum of sleep disorders including but not limited to insomnia, sleep related breathing disorders, parasomnias, obstructive sleep apnea (OSA) and nocturnal hypoventilation (NH). Sleep-related breathing disorders substantially increase both morbidity and mortality in ALS patients. In this review, we have discussed the ALS motor symptoms, sleep-related breathing disorders, behavioral abnormalities and sleep disturbing factors which impair the health-related quality of life.