A Cycle of Altered Proteasome and Reactive Oxygen Species Production in Renal Proximal Tubular Cells | Zendy

Nirmala Parajul | Zendy

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A Cycle of Altered Proteasome and Reactive Oxygen Species Production in Renal Proximal Tubular Cells

Author(s) -

Nirmala Parajul

Publication year - 2019

Publication title -

toxicology and forensic medicine - open journal

Language(s) - English

Resource type - Journals

ISSN - 2474-8978

DOI - 10.17140/tfmoj-4-128

Subject(s) - proteasome , peroxynitrite , bortezomib , reactive oxygen species , microbiology and biotechnology , mitochondrion , proteasome inhibitor , mitochondrial ros , small interfering rna , biology , gene knockdown , downregulation and upregulation , chemistry , cell culture , biochemistry , apoptosis , transfection , immunology , superoxide , multiple myeloma , enzyme , genetics , gene

An intricate relationship exists between the mitochondrial function and proteasome activity. Our recent report showed in a rat model of renal transplantation that mitochondrial dysfunction precedes compromised proteasome function and this results in a vicious cycle of mitochondrial injury and proteasome dysfunction. In this study, we studied whether reactive oxygen species (ROS) has a role in proteasome alteration in renal cells and vice versa.

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