Open AccessA Cycle of Altered Proteasome and Reactive Oxygen Species Production in Renal Proximal Tubular Cells
Author(s) -
Nirmala Parajuli
Publication year - 2019
Publication title -
toxicology and forensic medicine
Language(s) - English
Resource type - Journals
ISSN - 2474-8978
DOI - 10.17140/tfmoj-4-128
Subject(s) - proteasome , peroxynitrite , bortezomib , reactive oxygen species , microbiology and biotechnology , mitochondrion , proteasome inhibitor , mitochondrial ros , small interfering rna , biology , gene knockdown , downregulation and upregulation , chemistry , cell culture , biochemistry , apoptosis , transfection , immunology , superoxide , multiple myeloma , enzyme , genetics , gene
An intricate relationship exists between the mitochondrial function and proteasome activity. Our recent report showed in a rat model of renal transplantation that mitochondrial dysfunction precedes compromised proteasome function and this results in a vicious cycle of mitochondrial injury and proteasome dysfunction. In this study, we studied whether reactive oxygen species (ROS) has a role in proteasome alteration in renal cells and vice versa.