Open AccessHalting Coronavirus Replication
Author(s) -
Kira Smith
Publication year - 2020
Publication title -
epidemiology
Language(s) - English
Resource type - Journals
ISSN - 2473-4780
DOI - 10.17140/epoj-5-119
Subject(s) - coronavirus , sirtuin , viral replication , virology , replication (statistics) , biology , mechanism (biology) , covid-19 , virus , microbiology and biotechnology , genetics , disease , gene , medicine , infectious disease (medical specialty) , physics , pathology , quantum mechanics , acetylation
Sirtuin 1 (SIRT1) inhibitors can reduce replication of many viruses with certain characteristics similar to those of coronaviruses, while the p53 protein is another important factor in the down-regulation of viral growth. Tenovin is a class of small molecules that inhibit Sirtuin 1 and 2, in addition to activating the p53 protein, by means of regulating the interactions used by coronaviruses as a self-defense mechanism. By blocking virus growth and continuous replication, with already tested antiviral medicines, the promise of coronavirus disease 2019 (COVID-19) eradication exists.