Halting Coronavirus Replication | Zendy

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Halting Coronavirus Replication

Author(s) -

Kira Smith

Publication year - 2020

Publication title -

epidemiology - open journal

Language(s) - English

Resource type - Journals

ISSN - 2473-4780

DOI - 10.17140/epoj-5-119

Subject(s) - coronavirus , sirtuin , viral replication , virology , replication (statistics) , biology , mechanism (biology) , covid-19 , virus , microbiology and biotechnology , genetics , disease , gene , medicine , infectious disease (medical specialty) , physics , pathology , quantum mechanics , acetylation

Sirtuin 1 (SIRT1) inhibitors can reduce replication of many viruses with certain characteristics similar to those of coronaviruses, while the p53 protein is another important factor in the down-regulation of viral growth. Tenovin is a class of small molecules that inhibit Sirtuin 1 and 2, in addition to activating the p53 protein, by means of regulating the interactions used by coronaviruses as a self-defense mechanism. By blocking virus growth and continuous replication, with already tested antiviral medicines, the promise of coronavirus disease 2019 (COVID-19) eradication exists.

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