Open AccessAnastasis: Cell Survival Mechanism
Author(s) -
Abolaji Samson Olagunju,
Folashade G. Olorunfemi,
John Oluwafemi Teibo,
A Adewolu
Publication year - 2020
Publication title -
cancer studies and molecular medicine
Language(s) - English
Resource type - Journals
ISSN - 2377-1518
DOI - 10.17140/csmmoj-6-131
Subject(s) - programmed cell death , apoptosis , microbiology and biotechnology , cell , cancer cell , mechanism (biology) , cancer research , cell survival , biology , homeostasis , autophagy , metastasis , cancer , epithelial–mesenchymal transition , biochemistry , genetics , philosophy , epistemology
Equilibrium between cell survival and death is important for normal cell homeostasis and development and also for inhibiting pathologies particularly cancer. Anastasis is a natural cell recovery phenomenon that rescues cells from the brink of death or a mechanism by which cells recuperate from apoptotic lesions and return to its normal active and functioning state. Programmed cell death (apoptosis) was known to be an intrinsically irreversible cascade that commits cells to a rapid destruction. However, recent studies have demonstrated the possibility of recovering dying cells even at the late stages. Anastasis uses the usual pro-metastatic and pro-survival factors to inhibit apoptotic progression. Epithelial mesenchymal transition (EMT) activation and its related modulators is not only linked with cellular metastasis and survivability but also widely associated with the stemness of cancer cells.