Open AccessFocus on periodontal engineering by 3D printing technology – A systematic review
Author(s) -
Sesha Reddy,
Shishir Ram Shetty,
Raghavendra Shetty,
Venkataramana Vannala,
Shakeel Sk,
S Rajasekar
Publication year - 2020
Publication title -
journal of oral research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.127
H-Index - 4
eISSN - 0719-2479
pISSN - 0719-2460
DOI - 10.17126/joralres.2020.093
Subject(s) - scaffold , periodontal fiber , tissue engineering , 3d bioprinting , platelet rich fibrin , progenitor cell , stem cell , regeneration (biology) , fibrin , regenerative medicine , biomedical engineering , context (archaeology) , dentistry , mesenchymal stem cell , platelet lysate , periodontitis , 3d printing , medicine , engineering , pathology , microbiology and biotechnology , mechanical engineering , biology , immunology , paleontology
Three-dimensional (3D) bioprinting of cells is an emerging area of research but has not been explored yet in the context of periodontal tissue engineering. Objetive: This study reports on the optimization of the 3D bioprinting scaffolds and tissues used that could be applied clinically to seniors for the regenerative purpose to meet individual patient treatment needs. Material and Methods: We methodically explored the printability of various tissues (dentin pulp stem/progenitor cells, periodontal ligament stem/progenitor cells, alveolar bone stem/progenitor cells, advanced platelet-rich fibrin and injected platelet-rich fibrin) and scaffolds using 3D printers pertaining only to periodontal defects. The influence of different printing parameters with the help of scaffold to promote periodontal regeneration and to replace the lost structure has been evaluated. Results: This systematic evaluation enabled the selection of the most suited printing conditions for achieving high printing resolution, dimensional stability, and cell viability for 3D bioprinting of periodontal ligament cells. Conclusion: The optimized bioprinting system is the first step towards the reproducible manufacturing of cell laden, space maintaining scaffolds for the treatment of periodontal lesions.