Open AccessAssociation of serum level of 25-hydroxy vitamin D with Oral Lichen Planus. A case-control study.
Author(s) -
Mostafa Sadeghi,
Mahdieh Zarabadipour,
Faezeh Azmodeh,
Monirsadat Mirzadeh,
Ali Sarbazi Golezari
Publication year - 2020
Publication title -
journal of oral research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.127
H-Index - 4
eISSN - 0719-2479
pISSN - 0719-2460
DOI - 10.17126/joralres.2020.081
Subject(s) - oral lichen planus , medicine , vitamin d and neurology , vitamin , gastroenterology , vitamin c , case control study , physiology , immunology
Vitamin D deficiency is a global health problem that can be a risk factor for a broad range of diseases such as some autoimmune diseases. Due to the autoimmune base of lichen planus, it seems that a reduction of the serum level of vitamin D is related to lichen planus. In this study, we investigate the relation between serum level of vitamin D and oral lichen planus patients (OLP). Material and Methods: In this case-control study, 35 patients with OLP (including 15 men and 20 women) and 70 healthy volunteers (including 35 men and 35 women), aged between 30-60 years old, referred to Qazvin University of Medical Sciences were investigated. None of these volunteers had systemic diseases. Vitamin D levels were measured with ELFA (Enzyme Linked Fluorescent Assay) and the data was analyzed using the chi-squared test and t-test. Results: The mean serum level of vitamin D in the control group was 23.7±9ng/ml and in the case group was 18.12±8/7ng/ml. The results show that the serum level of vitamin D in patients with OLP is significantly less than in the control group (p<0.05). Conclusion: According to the results, the serum level of vitamin D in patients with OLP was significantly lower than that of healthy people.