Open AccessCharacteristics of lipid metabolism and the cardiovascular system in glycogenosis types I and III
Author(s) -
N. Polenova,
Т.В. Строкова,
A. V. Starodubova
Publication year - 2017
Publication title -
terapevtičeskij arhiv
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.181
H-Index - 14
eISSN - 2309-5342
pISSN - 0040-3660
DOI - 10.17116/terarkh201789888-94
Subject(s) - medicine , lipid metabolism , glycogen , glycogen storage disease , disease , metabolic disorder , endocrinology , glycogen storage disease type i , atherosclerotic cardiovascular disease
Glycogen storage disease (GSD) is an inherited metabolic disorder characterized by early childhood lipid metabolic disturbances with potentially proatherogenic effects. The review outlines the characteristics of impaired lipid composition and other changes in the cardiovascular system in GSD types I and III. It analyzes the factors enabling and inhibiting the development of atherosclerosis in patients with GSD. The review describes the paradox of vascular resistance to the development of early atherosclerosis despite the proatherogenic composition of lipids in the patients of this group.