Open AccessUse of pharmacogenetic testing to prevent adverse drug reactions during statin therapy
Author(s) -
Nikolai Rumyantsev,
В. Г. Кукес,
Р. Е. Казаков,
А. А. Rumyantsev,
Д А Сычев
Publication year - 2017
Publication title -
terapevtičeskij arhiv
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.181
H-Index - 14
eISSN - 2309-5342
pISSN - 0040-3660
DOI - 10.17116/terarkh201789182-87
Subject(s) - medicine , pharmacogenetics , adverse effect , slco1b1 , intensive care medicine , statin , drug , drug reaction , pharmacology , genotype , gene , biochemistry , chemistry
The number of patients receiving statins increases every year and due to the fact that they should take statins during their lives, the problem of their safety use comes to the forefront. The paper analyzes the safety of using the medications of this group and discusses the diagnosis of myopathies induced by statins and the occurrence of immune-mediated statin myopathies. It considers a personalized approach to prescribing statins, analyzes Russian and foreign experience in using pharmacogenetics to reduce the risk of myopathies, publishes the results of the authors’ experience in clinically introducing pharmacogenetic testing at hospitals, and analyzes the long-term results of determining the polymorphism of the SLCO1B1 gene for the prediction of the risk of adverse events when using statins and estimating patient compliance to prescribed treatment.