Open AccessPyridylimine palladium(II) complexes: one-pot synthesis and monoamine oxidase inhibition
Author(s) -
M. S. Denisov,
O. N. Gagarskikh,
Taisiya A. Utushkina
Publication year - 2021
Publication title -
vestnik permskogo universiteta. seriâ himiâ
Language(s) - English
Resource type - Journals
ISSN - 2223-1838
DOI - 10.17072/2223-1838-2021-1-30-58
Subject(s) - methylene , chemistry , monoamine oxidase , palladium , nitro , toxicity , aniline , acute toxicity , stereochemistry , methylene blue , oxidase test , medicinal chemistry , pharmacology , enzyme , biochemistry , biology , organic chemistry , catalysis , alkyl , photocatalysis
An efficient one-pot synthesis of the cis-pyridylimine palladium (II) complexes is reported. The compo- sition and structure were proved by NMR, IR, X-ray, and elemental analysis. The monoamine oxidase inhibition activity of synthesized complexes, including six complexes previously unknown, were inves- tigated on native mouse brains. Some of the synthesized compounds: cis-dichlorido-2,6-dimethyl-N- ((pyridin-2-yl)methylene)anilinepalladium(II), cis-dichlorido-4-nitro-N-((pyridin-2-yl)methylene)- anilinepalladium(II), and cis-dibromido-2,6-di(propan-2-yl)-N-((pyridin-2-yl)methylene)aniline- palladium(II) inhibited monoamine oxidase with moderate activity (IC50: 13.09–17.66 μМ). None of the studied compounds showed cytotoxic activity against HEK-293 cell line (human kidney embryonic cells). Acute systemic toxicity assay, that is conducted by intraperitoneal injection of cis-dichlorido-4- nitro-N-((pyridin-2-yl)methylene)anilinepalladium(II) indicated low toxicity (LD50> 5000 mg / kg) for outbred stocks mice. Bioavailability was assessed by logP’s measurement.