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Effects of fish oil supplementation on spatial memory in rats with pilocarpine‐induced epilepsy assessed using the Morris Water Maze test
Author(s) -
Nejm Mariana Bocca,
Victorino Daniella Balduino,
GuimarãesMarques Marcia Jonathas,
Scorza Carla Alessandra,
Finsterer Josef,
Scorza Fulvio Alexandre,
Cysneiros Roberta Monterazzo
Publication year - 2021
Publication title -
epileptic disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.673
H-Index - 53
eISSN - 1950-6945
pISSN - 1294-9361
DOI - 10.1684/epd.2021.1289
Subject(s) - morris water navigation task , pilocarpine , epilepsy , water maze , fish oil , temporal lobe , hippocampus , neuroscience , memory impairment , psychology , medicine , anesthesia , cognition , fish <actinopterygii> , biology , fishery
Objective . Patients with temporal lobe epilepsy (TLE) are at high risk of experiencing cognitive impairment. Such dysfunction is also observed in an animal model of TLE, the rat model of pilocarpine‐induced epilepsy. Methods . We investigated the effects of fish oil supplementation on spatial memory in rats with pilocarpine‐induced epilepsy using the Morris Water Maze (MWM) test. Results . Although rats with pilocarpine‐induced epilepsy treated with fish oil learned the platform location significantly faster by Day 7 of the acquisition phase, spatial memory performance of these rats was unaffected by fish oil supplementation during probe trials. Significance . Our study provides insights into the importance of considering nutraceutical strategies for enhancing cognitive abilities in patients with TLE.