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Auditory seizures in autoimmune epilepsy: a case with anti‐thyroid antibodies
Author(s) -
Varrasi Claudia,
Vecchio Domizia,
Magistrelli Luca,
Strigaro Gionata,
Tassi Laura,
Cantello Roberto
Publication year - 2017
Publication title -
epileptic disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.673
H-Index - 53
eISSN - 1950-6945
pISSN - 1294-9361
DOI - 10.1684/epd.2017.0904
Subject(s) - medicine , status epilepticus , encephalopathy , epilepsy , myoclonus , opsoclonus , autoimmune encephalitis , ataxia , pediatrics , autoantibody , immunology , anesthesia , antibody , psychiatry , biology , genetics , cell culture , neuroblastoma
In its classic presentation, Hashimoto's encephalopathy is an acute‐subacute complex neuropsychiatric syndrome with cognitive impairment, hallucinations, myoclonus, tremor or ataxia, associated with elevated anti‐thyroid antibodies. Corticoids and immunotherapy are dramatically effective. However, in some cases, not all the associated features are presented and this delays diagnosis and appropriate treatment. We describe a man with abrupt onset of recurrent auditory seizures resulting in refractory non‐convulsive status epilepticus. The patient was diagnosed with an autoimmune encephalopathy with elevated serum and CSF anti‐thyroid antibodies. None of the antiepileptic drugs were successful, however, following immune‐modulating therapy, the refractory non‐convulsive status epilepticus dramatically improved, as did the patient overall. We suggest that Hashimoto's encephalopathy should be suspected in otherwise healthy patients with unexplained new‐onset focal recurrent auditory seizures which do not respond to antiepileptic drugs. The presence of anti‐thyroid antibodies in the CSF supports this diagnosis.