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Benign adult familial myoclonus epilepsy is a progressive disorder: no longer idiopathic generalized epilepsy
Author(s) -
Hitomi Takefumi,
Kobayashi Katsuya,
Sakurai Takeyo,
Ueda Sakiho,
Jingami Naoto,
Kanazawa Kyoko,
Matsumoto Riki,
Takahashi Ryosuke,
Ikeda Akio
Publication year - 2016
Publication title -
epileptic disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.673
H-Index - 53
eISSN - 1950-6945
pISSN - 1294-9361
DOI - 10.1684/epd.2016.0807
Subject(s) - epilepsy , myoclonus , medicine , progressive myoclonus epilepsy , generalized epilepsy , electroencephalography , audiology , pediatrics , psychology , anesthesia , psychiatry
Background . Brain dysfunction in Japanese benign adult familial myoclonus epilepsy (BAFME) has not been elucidated. Aim . To clarify diffuse brain dysfunction as indicated by posterior dominant rhythm (PDR) slowing in patients with BAFME. Methods . The frequency of PDR on EEG was studied in 19 BAFME patients (50.6±15.7 years) and 38 age‐matched control subjects (50.1±14.5 years). We investigated the relationship between age and PDR in both groups. Results . PDR frequency in the patient group (9.1±0.7 Hz) was significantly slower than that of age‐matched control subjects (10.4±1.1 Hz; p <0.0001), regardless of the use of anticonvulsants. There was no significant difference in PDR slowing with age between groups. Conclusion . These findings suggest that Japanese patients with BAFME have mild diffuse brain dysfunction with minimal progression.