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Possible induction of multiple seizure foci due to parietal tumour and anti‐NMDAR antibody
Author(s) -
Matsumoto Riki,
Mikuni Nobuhiro,
Tanaka Keiko,
Usami Kiyohide,
Fukao Kenjiro,
Kunieda Takeharu,
Takahashi Yukitoshi,
Miyamoto Susumu,
Fukuyama Hidenao,
Takahashi Ryosuke,
Ikeda Akio
Publication year - 2015
Publication title -
epileptic disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.673
H-Index - 53
eISSN - 1950-6945
pISSN - 1294-9361
DOI - 10.1684/epd.2015.0725
Subject(s) - epileptogenesis , lesion , epilepsy , medicine , pathology , antibody , temporal lobe , neuroscience , immunology , biology
“Formes frustes” of encephalopathy associated with anti‐NMDAR antibody have been recently described in cases of chronic epilepsy. We report a young woman with a parietal lesion and anti‐NMDAR antibody who acquired bilateral, secondary epileptogenesis in the temporal lobes within a period as short as six years. Removal of the primary epileptogenic lesion of oligoastrocytoma in the right parietal lobe resulted in seizure freedom, disappearance of secondary foci, and substantial decrease of the antibody titre. Chronic exposure to anti‐NMDAR antibody, albeit at a low titre, may have resulted in a smoldering chronic course and relatively early acquisition of “reversible” secondary foci without development of a high degree of epileptogenicity and structural changes.