Premium
What are the best ways to deliver benzodiazepines in children/patients with prolonged convulsive seizures?
Author(s) -
Chin Richard FM
Publication year - 2014
Publication title -
epileptic disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.673
H-Index - 53
eISSN - 1950-6945
pISSN - 1294-9361
DOI - 10.1684/epd.2014.0684
Subject(s) - medicine , status epilepticus , anesthesia , epilepsy , lorazepam , antiepileptic drug , pediatrics , intensive care medicine , psychiatry
Aetiology is the main determinant of morbidity and mortality in convulsive status epilepticus (CSE) but longer seizure durations may also increase risk of worse outcome. Thirty minutes of seizure activity is usually the time period used in longstanding definitions of CSE but it is not acceptable to wait for 30 minutes before treatment. Whilst intravenous therapy is best, pre‐hospital treatment by a non‐intravenous route is most practical in treating children. Benzodiazepines are the main class of first‐line emergency antiepileptic drugs. This review will examine the available data on benzodiazepines according to: stability in the conditions of the emergency room services, drug absorption via non‐intravenous route, clinical efficacy and safety, and ease of delivery and social acceptability.