Open AccessMutltifaceted biological roles of leptin
Author(s) -
Rim Charchour,
Diane DufourRainfray,
Gilles Morineau,
Camille Vatier,
Soraya Fellahi,
Corinne Vigouroux,
Annelise Genoux,
Jacqueline Capeau,
JeanMarc Lacorte,
Christine Collet,
Charlotte Cuerq,
JeanPhilippe Bastard
Publication year - 2020
Publication title -
annales de biologie clinique
Language(s) - Uncategorized
Resource type - Journals
eISSN - 1950-6112
pISSN - 0003-3898
DOI - 10.1684/abc.2020.1560
Subject(s) - leptin , computational biology , medicine , biology , obesity
The identification of leptin allowed the discovery of a new endocrine system. This major adipokine controlling energy homeostasis is also involved in the regulation of neuroendocrine function and fertility. Unfortunately, leptin is not able to treat common obesity, which associates hyperleptinemia and resistance to the hormone. Conversely, treatment with recombinant leptin is effective in situations of leptin deficiency. Several pathophysiological situations associated with adipose tissue dysfunctions and abnormal regulation of leptin secretion are discussed in this review. The advantage of the potential use of the leptin assay in some pathophysiological conditions is proposed.