Open AccessAccreditation of the toxicological screening: recommendations of the SFBC-SFTA group
Author(s) -
Jérôme Guitton,
Jean-Michel Gaulier,
Antony Citterio-Quentin,
Emuri Abé,
Nathalie Allibé,
M. Bartoli,
Sabine Cohen,
Catherine Monteil-Ganière,
C. Garcia-Hejl,
Jérôme Grosjean,
Damien Richard,
Emilie Román,
Franck Saint-Marcoux,
Maëva Wendremaire
Publication year - 2019
Publication title -
annales de biologie clinique
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.167
H-Index - 27
eISSN - 1950-6112
pISSN - 0003-3898
DOI - 10.1684/abc.2019.1422
Subject(s) - humanities , physics , philosophy
Toxicological screening is a specific approach to analytical toxicology that uses analytical tools such as GC-MS, LC-UV (diode array) or LC-MS. Toxicological screening allows the detection and simultaneous identification of a large number of compounds. The results may be based on the use of one or more techniques. As part of the accreditation process for medical biology examinations according to standard NF EN ISO 15189, the group from SFTA and SFBC recommends an approach to accredit toxicological screening. Indeed, the complexity of the accreditation of this analysis comes in particular from the high number of compounds that can be detected. Validation parameters are discussed in the specific context of toxicological screening by considering two distinct approaches: the simple identification of compounds, or the identification and estimation of a range of concentration related to clinical outcomes.