Open AccessB-cell non-Hodgkin lymphoma discovery after observation of a platelet satellitism around atypical lymphocytes
Author(s) -
Anne Gatignol,
Marie Amirault,
Éric Legac,
Julien Decker
Publication year - 2019
Publication title -
annales de biologie clinique
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.167
H-Index - 27
eISSN - 1950-6112
pISSN - 0003-3898
DOI - 10.1684/abc.2018.1406
Subject(s) - immunophenotyping , medicine , platelet , flow cytometry , cd5 , population , lymphoma , bone marrow , pathology , complete blood count , immunology , cd11c , blood cell , biology , phenotype , biochemistry , environmental health , gene
We report the case of an 83-year-old woman admitted to the accident and emergency unit for pneumopathy. The blood cell count on the DXH automaton (Coulter® ™ UniCel® DxH) found a normochromic and normocytic anemia, anormal platelet count and subnormal leukocyte formula. The only alarm raised by the automaton was the presence of a basocytosis. A control of the leucocyte count by flow cytometry and blood smear has been done. It revealed there was no basocytosis, but showed the presence of an atypical monomorphic lymphocytes B population (T/B < 1 ratio in flow cytometry), around which platelets aggregated. The lymphocytic immunophenotyping allowed us to highlight the presence of a CD5+ B clonal subpopulation.