Open AccessPodocyte Aging: Why and How Getting Old Matters
Author(s) -
Stuart J. Shankland,
Yuliang Wang,
Andrey S. Shaw,
Joshua C. Vaughan,
Jeffrey W. Pippin,
Oliver Wessely
Publication year - 2021
Publication title -
journal of the american society of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.451
H-Index - 279
eISSN - 1533-3450
pISSN - 1046-6673
DOI - 10.1681/asn.2021050614
Subject(s) - podocyte , context (archaeology) , disease , kidney disease , cellular aging , medicine , glomerulosclerosis , biology , kidney glomerulus , kidney , renal glomerulus , affect (linguistics) , microbiology and biotechnology , rapidly progressive glomerulonephritis , kidney development , cancer research , molecular cell biology , slit diaphragm , signal transduction , cellular senescence , cell growth , bioinformatics , glomerulonephritis , neuroscience
The effects of healthy aging on the kidney, and how these effects intersect with superimposed diseases, are highly relevant in the context of the population’s increasing longevity. Age-associated changes to podocytes, which are terminally differentiated glomerular epithelial cells, adversely affect kidney health. This review discusses the molecular and cellular mechanisms underlying podocyte aging, how these mechanisms might be augmented by disease in the aged kidney, and approaches to mitigate progressive damage to podocytes. Furthermore, we address how biologic pathways such as those associated with cellular growth confound aging in humans and rodents.
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