Open AccessNew Treatment Strategies for Malignant Gliomas
Author(s) -
Avgeropoulos Nicholas G.,
Batchelor Tracy T.
Publication year - 1999
Publication title -
the oncologist
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.176
H-Index - 164
eISSN - 1549-490X
pISSN - 1083-7159
DOI - 10.1634/theoncologist.4-3-209
Subject(s) - medicine , temozolomide , clinical trial , angiogenesis , glioma , bevacizumab , oncology , brain tumor , glioblastoma , optimism , pharmacology , cancer research , chemotherapy , pathology , psychology , social psychology
Although survival in patients with malignant gliomas remains limited, there is renewed optimism with the emergence of novel treatment strategies. Cytotoxic agents such as temozolomide and CPT‐11 have shown promising clinical activity. Biological treatments for brain tumors, including antisense oligonucleotides, gene therapy, and angiogenesis inhibitors, are also being evaluated in clinical trials. Delivery strategies have been developed to overcome challenges presented by the blood‐brain barrier. These noteworthy treatments, alone or in combination, may ultimately prolong survival and enhance quality of life in this group of patients.