Open AccessStrategies of Antiretroviral Therapy in Adults
Author(s) -
Bartlett John A.
Publication year - 1998
Publication title -
the oncologist
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.176
H-Index - 164
eISSN - 1549-490X
pISSN - 1083-7159
DOI - 10.1634/theoncologist.3-2-111
Subject(s) - medicine , antiretroviral therapy , intensive care medicine , human immunodeficiency virus (hiv) , oncology , virology , viral load
Recent progress in antiretroviral treatment has led to dramatic improvements in HIV‐related morbidity and mortality. These improvements have been fostered by advances in our understanding of HIV‐related pathogenesis, the use of plasma HIV RNA levels to monitor patients, and the availability of 11 licensed antiretroviral drugs, including the potent protease inhibitors. Numerous drug combinations, especially those containing three agents, can suppress plasma HIV RNA levels below the lower limit of detection in the majority of treated patients. However, the limitations of this therapeutic response—patient compliance, drug resistance, and a residual burden of chronically infected cells which are refractory to treatment—should be familiar to the oncologist.