Open AccessHow Do the Accrual Pattern and Follow‐Up Duration Affect the Hazard Ratio Estimate When the Proportional Hazards Assumption Is Violated?
Author(s) -
Horiguchi Miki,
Hassett Michael J.,
Uno Hajime
Publication year - 2019
Publication title -
the oncologist
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.176
H-Index - 164
eISSN - 1549-490X
pISSN - 1083-7159
DOI - 10.1634/theoncologist.2018-0141
Subject(s) - medicine , proportional hazards model , affect (linguistics) , hazard ratio , accrual , statistics , duration (music) , hazard , econometrics , confidence interval , mathematics , economics , earnings , philosophy , linguistics , chemistry , accounting , organic chemistry , art , literature
In randomized clinical trials, the magnitude of the treatment effect is often reported using the hazard ratio (HR) even when the proportional hazards (PH) assumption is not met. Conducting numerical studies, this commentary illustrates how/why the HR estimate via the standard Cox's procedure is difficult to interpret even as an “average” treatment effect for non‐PH cases.