Open AccessFeasibility and Efficacy of Microwave Ablation Combined with Iodine‐125 Seed Implantation in Local Control of Recurrent Retroperitoneal Liposarcomas: Initial Clinical Experience
Author(s) -
Lu Mingjian,
Yao Wang,
Zhang Tao,
Fan Wenzhe,
Zhong Zhihui,
Li Jiaping,
Zhang Fujun
Publication year - 2017
Publication title -
the oncologist
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.176
H-Index - 164
eISSN - 1549-490X
pISSN - 1083-7159
DOI - 10.1634/theoncologist.2016-0499
Subject(s) - medicine , microwave ablation , surgery , prospective cohort study , ablation , complication , radiology , clinical effectiveness , percutaneous
The objective of the present study was to evaluate the feasibility, safety, and short‐term efficacy of microwave ablation (MWA) combined with iodine‐125 ( 125 I) seed implantation in recurrent retroperitoneal liposarcomas (rRPLs). Materials and Methods From September 2012 to March 2015, 11 patients were enrolled in this prospective study. Eleven tumors (median, 9 cm; range, 5.5–12.5 cm) were treated with computerized tomography‐guided MWA for 11 sessions and 125 I seed implantation for 18 sessions. 125 I seed implantation was performed 4 weeks after MWA. Results There were no procedure‐related deaths. Post‐MWA pain (grade ≥2) was the most common complication (6 of 11 patients, 54.5%), and fever (grade ≥2) was observed in two patients. Reversible nerve injury, defined as transient limb paresthesia or leg weakness, was observed in one patient. There were fewer complications associated with the 125 I seed implantation procedure compared with the MWA procedure. All 11 patients who underwent the MWA procedure achieved a partial response (PR), according to the modified Response Evaluation Criteria in Solid Tumors, 1 month post‐ablation; after 125 I seed implantation was performed, a complete response was observed in three, five, and six target tumors in 3, 6, and 12 months, respectively. Conclusion In selected patients with rRPLs, MWA combined with 125 I seed implantation is feasible and safe with favorable local control efficacy. Implications for Practice This study evaluated the feasibility, safety, and short‐term efficacy of microwave ablation (MWA) combined with iodine‐125 ( 125 I) seed implantation in recurrent retroperitoneal liposarcomas (rRPLs). Results suggest that a single session of MWA may be not sufficient in large‐volume rRPLs and that as a supplement treatment, 125 I seed implantation is safe and easy accessible. MWA combined with 125 I seed has excellent local control effectiveness, and long‐term efficacy and survival benefit still need to be more comprehensively evaluated.