Open AccessA Host‐Dependent Prognostic Model for Elderly Patients with Diffuse Large B‐Cell Lymphoma
Author(s) -
Miura Katsuhiro,
Konishi Jun,
Miyake Takaaki,
Makita Masanori,
Hojo Atsuko,
Masaki Yasufumi,
Uno Masatoshi,
Ozaki Jun,
Yoshida Chikamasa,
Niiya Daigo,
Kitazume Koichi,
Maeda Yoshinobu,
Takizawa Jun,
Sakai Rika,
Yano Tomofumi,
Yamamoto Kazuhiko,
Sunami Kazutaka,
Hiramatsu Yasushi,
Aoyama Kazutoshi,
Tsujimura Hideki,
Murakami Jun,
Hatta Yoshihiro,
Kanno Masatoshi
Publication year - 2017
Publication title -
the oncologist
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.176
H-Index - 164
eISSN - 1549-490X
pISSN - 1083-7159
DOI - 10.1634/theoncologist.2016-0260
Subject(s) - medicine , international prognostic index , diffuse large b cell lymphoma , rituximab , cyclophosphamide , chop , prednisone , anthracycline , vincristine , tolerability , lymphoma , cohort , oncology , gastroenterology , adverse effect , chemotherapy , cancer , breast cancer
Background Decision‐making models for elderly patients with diffuse large B‐cell lymphoma (DLBCL) treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R‐CHOP) are in great demand. Patients and Methods The Society of Lymphoma Treatment in Japan (SoLT‐J), in collaboration with the West‐Japan Hematology and Oncology Group (West‐JHOG), collected and retrospectively analyzed the clinical records of ≥65‐year‐old patients with DLBCL treated with R‐CHOP from 19 sites across Japan to build an algorithm that can stratify adherence to R‐CHOP. Results A total of 836 patients with a median age of 74 years (range, 65–96 years) were analyzed. In the SoLT‐J cohort ( n = 555), age >75 years, serum albumin level <3.7 g/dL, and Charlson Comorbidity Index score ≥3 were independent adverse risk factors and were defined as the Age, Comorbidities, and Albumin (ACA) index. Based on their ACA index score, patients were categorized into “excellent” (0 points), “good” (1 point), “moderate” (2 points), and “poor” (3 points) groups. This grouping effectively discriminated the 3‐year overall survival rates, mean relative total doses (or relative dose intensity) of anthracycline and cyclophosphamide, unanticipated R‐CHOP discontinuance rates, febrile neutropenia rates, and treatment‐related death rates. Additionally, the ACA index showed comparable results for these clinical parameters when it was applied to the West‐JHOG cohort ( n = 281). Conclusion The ACA index has the ability to stratify the prognosis, tolerability to cytotoxic drugs, and adherence to treatment of elderly patients with DLBCL treated with R‐CHOP. Implications for Practice Currently, little is known regarding how to identify elderly patients with diffuse large B‐cell lymphoma who may tolerate a full dose of chemotherapy or to what extent cytotoxic drugs should be reduced in some specific conditions. The Society of Lymphoma Treatment in Japan developed a host‐dependent prognostic model consisting of higher age (>75 years), hypoalbuminemia (<3.7 g/dL), and higher Charlson Comorbidity Index score (≥3) for such elderly patients. This model can stratify the prognosis, tolerability to cytotoxic drugs, and adherence to treatment of these patients and thus help clinicians in formulating personalized treatment strategies for this growing patient population.