Open AccessIonophore Antibiotics as Cancer Stem Cell‐Selective Drugs: Open Questions
Author(s) -
Boesch Maximilian,
Sopper Sieghart,
Wolf Dominik
Publication year - 2016
Publication title -
the oncologist
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.176
H-Index - 164
eISSN - 1549-490X
pISSN - 1083-7159
DOI - 10.1634/theoncologist.2016-0159
Subject(s) - ionophore , efflux , antibiotics , medicine , cytotoxicity , cancer stem cell , drug , drug resistance , cancer , stem cell , cancer cell , pharmacology , cancer research , microbiology and biotechnology , biochemistry , biology , in vitro , calcium
Ionophore antibiotics are promising compounds with potent anticancer and anti‐cancer stem cell (anti‐CSC) activity. However, resistance mediated by drug transporters potentially confines their use to CSC populations that do not exhibit appreciable drug efflux capacity. Further research is required to delineate which CSC subsets are likely to be susceptible to ionophore antibiotic cytotoxicity.