Open AccessDrug Development for Hepatocellular Carcinoma: Knowing the Past Helps to Understand the Future
Author(s) -
Chan Stephen L.
Publication year - 2014
Publication title -
the oncologist
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.176
H-Index - 164
eISSN - 1549-490X
pISSN - 1083-7159
DOI - 10.1634/theoncologist.2014-0304
Subject(s) - hepatocellular carcinoma , cirrhosis , patience , drug development , homogeneous , identification (biology) , disease , selection (genetic algorithm) , drug , medicine , population , drug discovery , psychology , bioinformatics , computer science , pharmacology , biology , environmental health , social psychology , artificial intelligence , physics , botany , thermodynamics
Hepatocellular carcinoma (HCC) is a highly complicated disease characterized by comorbid cirrhosis and disease heterogeneity. Given multiple failures in the past, we need to learn from previous experiences and generate novel ideas to increase the chance of success. More effort and patience should be exercised in the selection of a homogeneous patient population and identification of predictive markers during drug development for HCC.