Open AccessThe Importance of Drug Scheduling in Cancer Chemotherapy: Etoposide as an Example
Author(s) -
Hande Kenneth R.
Publication year - 1996
Publication title -
the oncologist
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.176
H-Index - 164
eISSN - 1549-490X
pISSN - 1083-7159
DOI - 10.1634/theoncologist.1-4-234
Subject(s) - etoposide , medicine , drug , pharmacokinetics , cancer chemotherapy , pharmacology , chemotherapy , schedule , oncology , anticancer drug , computer science , operating system
Etoposide is a drug whose antineoplastic activity is dependent on the schedule of drug administration. This article reviews the rationale for a prolonged schedule of etoposide administration and the therapeutic results of use of such a schedule in the treatment of cancer. The pharmacology of etoposide is also reviewed, with particular attention paid to the pharmacokinetics of oral etoposide and etoposide plasma concentrations associated with cytotoxicity.