Open AccessPlasticity of Bone Marrow–Derived Stem Cells
Author(s) -
Grove Joanna E.,
Bruscia Emanuela,
Krause Diane S.
Publication year - 2004
Publication title -
stem cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.159
H-Index - 229
eISSN - 1549-4918
pISSN - 1066-5099
DOI - 10.1634/stemcells.22-4-487
Subject(s) - stem cell , biology , clinical uses of mesenchymal stem cells , stem cell transplantation for articular cartilage repair , adult stem cell , bone marrow , haematopoiesis , mesenchymal stem cell , microbiology and biotechnology , stem cell theory of aging , hematopoietic stem cell , endothelial stem cell , immunology , stem cell factor , genetics , in vitro
Stem cell plasticity refers to the ability of adult stem cells to acquire mature phenotypes that are different from their tissue of origin. Adult bone marrow cells (BMCs) include two populations of bone marrow stem cells (BMCs): hematopoietic stem cells (HSCs), which give rise to all mature lineages of blood, and mesenchymal stem cells (MSCs), which can differentiate into bone, cartilage, and fat. In this article, we review the literature that lends credibility to the theory that highly plastic BMCs have a role in maintenance and repair of nonhematopoietic tissue. We discuss the possible mechanisms by which this may occur. Also reviewed is the possibility that adult BMCs can change their gene expression profile after fusion with a mature cell, which has brought into question whether this stem cell plasticity is real.