Open AccessPeriodontal Ligament Stem Cell‐Mediated Treatment for Periodontitis in Miniature Swine
Author(s) -
Liu Yi,
Zheng Ying,
Ding Gang,
Fang Dianji,
Zhang Chunmei,
Bartold Peter Mark,
Gronthos Stan,
Shi Songtao,
Wang Songlin
Publication year - 2008
Publication title -
stem cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.159
H-Index - 229
eISSN - 1549-4918
pISSN - 1066-5099
DOI - 10.1634/stemcells.2007-0734
Subject(s) - periodontal ligament stem cells , periodontal fiber , periodontitis , stem cell , dentistry , regeneration (biology) , medicine , biology , pathology , biochemistry , alkaline phosphatase , genetics , enzyme , microbiology and biotechnology
Periodontitis is a periodontal tissue infectious disease and the most common cause for tooth loss in adults. It has been linked to many systemic disorders, such as coronary artery disease, stroke, and diabetes. At present, there is no ideal therapeutic approach to cure periodontitis and achieve optimal periodontal tissue regeneration. In this study, we explored the potential of using autologous periodontal ligament stem cells (PDLSCs) to treat periodontal defects in a porcine model of periodontitis. The periodontal lesion was generated in the first molars area of miniature pigs by the surgical removal of bone and subsequent silk ligament suture around the cervical portion of the tooth. Autologous PDLSCs were obtained from extracted teeth of the miniature pigs and then expanded ex vivo to enrich PDLSC numbers. When transplanted into the surgically created periodontal defect areas, PDLSCs were capable of regenerating periodontal tissues, leading to a favorable treatment for periodontitis. This study demonstrates the feasibility of using stem cell‐mediated tissue engineering to treat periodontal diseases. Disclosure of potential conflicts of interest is found at the end of this article.