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The early, random nature of X inactivation should cause related cells to have similar, but distinctive, active X chromosomes. We assessed the frequency of stem cell plasticity using X inactivation proportions (XIPs), determined at the human androgen receptor locus, in paired tissue samples from healthy individuals. Tissues sampled were stomach ( n  = 18 informative females), duodenum ( n  = 18), colon ( n  = 10) with corresponding peripheral blood samples ( n  = 33), and varicose veins ( n  = 28) with corresponding T cells ( n  = 26) and peripheral blood granulocytes ( n  = 25). XIPs from samples thought to have common stem cell origins were highly correlated: multiple samples from single vein,  r  = .80 ( n  = 24); T cells versus granulocytes,  r  = .67 ( n  = 23); duodenum versus stomach,  r  = .63 ( n  = 12). Blood cells and vessels are derived from a common hemangioblast, but XIP correlations were moderate or poor: vein versus T cells,  r  = .42 ( n  = 26); vein versus granulocytes,  r  = .11 ( n  = 25). X inactivation is believed to be a late process in gut, especially hind‐gut, with corresponding independence from blood precursors. Correlations with blood cells were low: stomach,  r  = .23 (18); duodenum,  r  = .21 (18); colon,  r  = .034 (10). Any crossover of stem cells between different organs during adult life should increase correlations with age; no such increase was seen. This study confirms that XIPs can be used to track stem cell populations, provides a theoretical basis for the power of such studies, and indicates that hemopoietic stem cell plasticity is, at most, uncommon in normal humans.

X Inactivation Patterns of Closely, but Not Distantly, Related Cells Are Highly Correlated: Little Evidence for Stem Cell Plasticity in Normal Females