Open AccessMacrophage Colony‐Stimulating Factor (M‐CSF), As Well As Granulocyte Colony‐Stimulating Factor (G‐CSF), Accelerates Neovascularization
Author(s) -
Minamino Keizo,
Adachi Yasushi,
Okigaki Mitsuhiko,
Ito Hidefumi,
Togawa Yoshimi,
Fujitha Kengo,
Tomita Minoru,
Suzuki Yasuhiro,
Zhang Yuming,
Iwasaki Masayoshi,
Nakano Keiji,
Koike Yasushi,
Matsubara Hiroaki,
Iwasaka Toshiji,
Matsumura Miyo,
Ikehara Susumu
Publication year - 2005
Publication title -
stem cells
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.159
H-Index - 229
eISSN - 1549-4918
pISSN - 1066-5099
DOI - 10.1634/stemcells.2004-0190
Subject(s) - biology , granulocyte macrophage colony stimulating factor , granulocyte macrophage colony stimulating factor receptor , colony stimulating factor , macrophage colony stimulating factor , granulocyte colony stimulating factor , granulocyte , immunology , growth factor , macrophage , neovascularization , cancer research , microbiology and biotechnology , cytokine , stem cell , angiogenesis , haematopoiesis , biochemistry , in vitro , genetics , chemotherapy , receptor
It has been reported that bone marrow cells (BMCs) differentiate into endothelial cells of blood vessels, and that granulocyte colony‐stimulating factor (G‐CSF) mobilizes progenitors in the BMCs to the peripheral blood, while macrophage colony‐stimulating factor (M‐CSF) augments the production of monocytes. We examined whether M‐CSF augments the differentiation of BMCs into endothelial cells of blood vessels using a hindlimb‐ischemic model. Either G‐CSF or M‐CSF, or both, was administered to the hindlimb‐ischemic mice for 3 days. Both M‐CSF and G‐CSF augmented the differentiation of BMCs into endothelial cells of blood vessels through vascular endothelial cell growth factor (VEGF), resulting in early recovery of blood flow in the ischemic limbs.