Open AccessUpregulation of h-TERT and Ki-67 in ectopic endometrium is associated with recurrence of endometriosis
Author(s) -
Jie Luo,
Zhimin Song,
Tao Zhang,
Ketan Chu,
Jingyi Li,
Jianhong Zhou,
Jizhen Lin
Publication year - 2022
Publication title -
journal of zhejiang university. science b
Language(s) - English
Resource type - Journals
eISSN - 1862-1783
pISSN - 1673-1581
DOI - 10.1631/jzus.b2100502
Subject(s) - endometriosis , medicine , pelvic pain , infertility , quality of life (healthcare) , pelvic endometriosis , adverse effect , disease , gynecology , surgery , pregnancy , nursing , biology , genetics
At present, endometriosis remains a worldwide health burden, with the main symptoms of dysmenorrhea, chronic pelvic pain, and infertility, markedly reducing the quality of life (de Ziegler et al., 2010). Although there is no proof that the disease is associated with high mortality, this disorder can significantly contribute to the deterioration of women's general well-being (McPeak et al., 2018). The main current treatment for endometriosis is surgery to remove endometriotic lesions; however, the recurrence rate following surgical treatment is as high as 21.5% at two years and 40.0%-50.0% at five years post-surgery (Koga et al., 2015). To prevent recurrence, adjuvant treatment with drugs after surgery is recommended to prolong relapse-free intervals. However, it is inconvenient for patients to continuously use such medications in terms of adverse effects and cost (Turk, 2002).