Open AccessA near-infrared spectroscopy-based end-point determination method for the blending process of Dahuang soda tablets
Author(s) -
Sijun Wu,
Ping Qiu,
Pian Li,
Zheng Li,
Wenlong Li
Publication year - 2020
Publication title -
journal of zhejiang university. science b
Language(s) - English
Resource type - Journals
eISSN - 1862-1783
pISSN - 1673-1581
DOI - 10.1631/jzus.b2000417
Subject(s) - partial least squares regression , magnesium stearate , principal component analysis , materials science , biological system , process analytical technology , robustness (evolution) , chemometrics , homogeneity (statistics) , near infrared spectroscopy , chromatography , process engineering , analytical chemistry (journal) , computer science , dosage form , chemistry , chemical engineering , artificial intelligence , machine learning , optics , biochemistry , bioprocess , gene , engineering , biology , physics
This study is aimed to explore the blending process of Dahuang soda tablets. These are composed of two active pharmaceutical ingredients (APIs, emodin and emodin methyl ether) and four kinds of excipients (sodium bicarbonate, starch, sucrose, and magnesium stearate). Also, the objective is to develop a more robust model to determine the blending end-point.